13 Octubre 2016
Administrator

Gaetano Cuccio, Marianno Franzini

 

Gaetano Cucci

Doctor II Master Oxygen-Ozone University of Pavia, Pavia, Italy

 

Marianno Franzini

Oxygen-Ozone Therapy Scientific Society, Gorle (BG), Italy

 

Abstract

 

The panniculosis or edematous fibrosclerotic panniculopathy (PEFS), commonly called cellulite is a subcutaneous adipose disease that afflicts the vast majority of women at all ages. PEFS is framed as a subcutaneous adipose suffering from venous and lymphatic stasis whose etiology is multifactorial. Many others are the implications and clinical relapses of diseases of inflammatory or autoimmune basis that determine disease states with involvement of the patient’s general conditions. The oxygen-ozone therapy, thanks to its abilities of improving the rheological properties of the microcirculation, immuno-modulating and anti-inflammatory abnormalities, arises as adjuvant and is a valid method, which is also an alternative compared to conventional protocols.

 

Keywords

 

Cellulite; Oxygen-ozone; Adipose Tissue; Microcirculation.

 

 

Más Información

09 Febrero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?

Author

Sagai, Masaru

Author

Bocci, Velio

Abstract

ABSTRACT: The potential mechanisms of action of ozone therapy are reviewed in this paper. The therapeutic efficacy of ozone therapy may be partly due the controlled and moderate oxidative stress produced by the reactions of ozone with several biological components. The line between effectiveness and toxicity of ozone may be dependent on the strength of the oxidative stress. As with exercise, it is well known that moderate exercise is good for health, whereas excessive exercise is not.Severe oxidative stress activates nuclear transcriptional factor kappa B (NFκB), resulting in an inflammatory response and tissue injury via the production of COX2, PGE2, and cytokines. However, moderate oxidative stress activates another nuclear transcriptional factor, nuclear factor-erythroid 2-related factor 2 (Nrf2). Nrf2 then induces the transcription of antioxidant response elements (ARE). Transcription of ARE results in the production of numerous antioxidant enzymes, such as SOD, GPx, glutathione-s-transferase(GSTr), catalase (CAT), heme-oxygenase-1 (HO-1), NADPH-quinone-oxidoreductase (NQO-1), phase II enzymes of drug metabolism and heat shock proteins (HSP). Both free antioxidants and anti-oxidative enzymes not only protect cells from oxidation and inflammation but they may be able to reverse the chronic oxidative stress. Based on these observations, ozone therapy may also activate Nrf2 via moderate oxidative stress, and suppress NFκB and inflammatory responses. Furthermore, activation of Nrf2 results in protection against neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases. Mild immune responses are induced via other nuclear transcriptional factors, such as nuclear factor of activated T-cells (NFAT) and activated protein-1 (AP-1).Additionally, the effectiveness of ozone therapy in vascular diseases may also be explained by the activation of another nuclear transcriptional factor, hypoxia inducible factor-1α (HIF-1a), which is also induced via moderate oxidative stress. Recently these concepts have become widely accepted. The versatility of ozone in treating vascular and degenerative diseases as well as skin lesions, hernial disc and primary root carious lesions in children is emphasized. Further researches able to elucidate whether the mechanisms of action of ozone therapy involve nuclear transcription factors, such as Nrf2, NFAT, AP-1, and HIF-1α are warranted.

Publication

Medical Gas Research

Volume

1

Pages

29

Date

2011

Journal Abbr

Med Gas Res

DOI

10.1186/2045-9912-1-29

ISSN

2045-9912

Short Title

Mechanisms of Action Involved in Ozone Therapy

URL

http://www.ncbi.nlm.nih.gov/pubmed/22185664

Accessed

2012-04-06 11:20:01

Library Catalog

NCBI PubMed

Extra

PMID: 22185664

Tags

 

 

 

30 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

To what extent does ozone therapy need a real biochemical control system? Assessment and importance of oxidative stress

Author

Hernández, Frank Antonio

Abstract

Ozone therapy is not officially allowed in many countries, but private medical services are using this therapy worldwide. However, appropriate control systems to assess the benefits and risks of systemic ozone therapy are not always used and in such cases the treatment is based on anecdotal reports. Oxidative stress phenomenon is becoming a highlighted biological process for ozone therapy because it is deeply involved in its mechanism of action. On the contrary, ozone therapy is an efficient regulator of the oxidative stress processes. In terms of therapeutic effects, it is convenient to know the metabolic status of the organism to face new oxidative challenges before and during ozone therapy applications. Oxidative stress is also important because it is involved as a cause or effect of many diseases. Since the 1990s, there has been the necessity of developing reliable systems for measuring oxidative stress in humans. In this sense, we have proposed a system for oxidative stress diagnosis that can serve as a control system for systemic ozone therapy applications. The system is based on the blood measurement of eight biomarkers (GSH, GPx, GST, SOD, CAT, DC, SRATB, and HPT) and the interpretation of these values by a computer-developed algorithm yielding four new indices (total antioxidant activity, total prooxidant activity, redox index and grade of oxidative stress). The system shows the patient's redox status and estimation of the oxidative stress level, with this information being relevant regarding implications on dosage and therapeutic effectiveness of ozone therapy.

Publication

Archives of Medical Research

Volume

38

Issue

5

Pages

571-578

Date

Jul 2007

Journal Abbr

Arch. Med. Res

DOI

10.1016/j.arcmed.2007.03.002

ISSN

0188-4409

Short Title

To what extent does ozone therapy need a real biochemical control system?

URL

http://www.ncbi.nlm.nih.gov/pubmed/17560465

Accessed

2010-02-24 18:40:37

Library Catalog

NCBI PubMed

Extra

PMID: 17560465

Tags