The influence of intraportal ozone therapy on the functional condition of liver in a complex treatment of obturative cholestasis

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en 30 Enero 2015

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Item Type

Journal Article

Title

[The influence of intraportal ozone therapy on the functional condition of liver in a complex treatment of obturative cholestasis]

Author

Belyaev, S A

Author

Belyaev, A N

Author

Kozlov, S A

Abstract

The results of treatment of 69 patients with obstructive jaundice were studied, for whom intravenous (the 1st group of 36 patients) and intraportal (the 2nd group of 33 patients) ozone therapy was applied in the pre- and postsurgical period in addition to traditional therapy. Ozonated saline solution (OSS) was produced by barbotage of 0.9% of sodium chloride solution with ozone-oxygen mixture. The ozone concentration in ozone-oxygen mixture at the resonator output was 2500 mkg/l, the barbotage time was 10 min. For patients of the first group with total bilirubin of over 200 µmol/l the intravenous ozone therapy was carried out within three days in the pre-surgical period and within 5 days after operation. For patients of the second group intraportal infusions were made by means of intraoperative catheterization of umbilical vein at the rate of 30-40 drops per minute within 5-7 days. Indicators of the liver functional state, endogene intoxication, lipid peroxidation (LPO) products were determined in venous blood plasma of patients in the both groups by conventional methods. It was found that the hepatocyte function normalization occurred within shorter time under intraportal ozone therapy than in patients of the first group. It was associated with the more marked activation of the antioxidant system of the liver. Key words: obstructive cholestatis, intraportal ozone therapy, lipoperoxidation, functional state of the liver.

Publication

Meditsinskii almanakh

Issue

3

Pages

96-98

Date

2013

Journal Abbr

Meditsinskii almanakh

Language

Russian

ISSN

1997-7689

URL

http://www.medalmanac.ru/archive/year_2013/numb_3_13/Surgery/?doc=2156

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