30 Enero 2015
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gregorcuba

Item Type

Journal Article

Title

[The influence of intraportal ozone therapy on the functional condition of liver in a complex treatment of obturative cholestasis]

Author

Belyaev, S A

Author

Belyaev, A N

Author

Kozlov, S A

Abstract

The results of treatment of 69 patients with obstructive jaundice were studied, for whom intravenous (the 1st group of 36 patients) and intraportal (the 2nd group of 33 patients) ozone therapy was applied in the pre- and postsurgical period in addition to traditional therapy. Ozonated saline solution (OSS) was produced by barbotage of 0.9% of sodium chloride solution with ozone-oxygen mixture. The ozone concentration in ozone-oxygen mixture at the resonator output was 2500 mkg/l, the barbotage time was 10 min. For patients of the first group with total bilirubin of over 200 µmol/l the intravenous ozone therapy was carried out within three days in the pre-surgical period and within 5 days after operation. For patients of the second group intraportal infusions were made by means of intraoperative catheterization of umbilical vein at the rate of 30-40 drops per minute within 5-7 days. Indicators of the liver functional state, endogene intoxication, lipid peroxidation (LPO) products were determined in venous blood plasma of patients in the both groups by conventional methods. It was found that the hepatocyte function normalization occurred within shorter time under intraportal ozone therapy than in patients of the first group. It was associated with the more marked activation of the antioxidant system of the liver. Key words: obstructive cholestatis, intraportal ozone therapy, lipoperoxidation, functional state of the liver.

Publication

Meditsinskii almanakh

Issue

3

Pages

96-98

Date

2013

Journal Abbr

Meditsinskii almanakh

Language

Russian

ISSN

1997-7689

URL

http://www.medalmanac.ru/archive/year_2013/numb_3_13/Surgery/?doc=2156

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30 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

The effect of rectal ozone on the portal vein oxygenation and pharmacokinetics of propranolol in liver cirrhosis (a preliminary human study)

Author

Zaky, Saad

Author

Fouad, Ehab Ahmad

Author

Kotb, Hassan Ibrahim Mohamad

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT •Experimental work has shown that ozone protected both the liver and kidney from reperfusion injury through release of mediators of nitric oxide. Rectal ozone increased oxygenation in the intestinal wall (250%), portal vein (134%) and liver parenchyma (127%) in experimental animals. The kinetics of propranolol and other oxidation-dependent drugs have been reported to be affected due to liver cirrhosis. Several experimental studies have reported improved propranolol clearance through increased hepatic blood flow. WHAT THIS STUDY ADDS •This current study looked for evidence in man of improved hepato-splanchnic oxygenation after rectal ozone. Changes in metabolic pathway via measurement of portal vein oxygenation and the kinetic profile changes of propranolol as an index drug for metabolic oxidation in the liver were measured. •This small preliminary clinical study showed that improved propranolol clearance was obtained by rectal ozone in humans for the first time. In addition there was also evidence of improved portal vein oxygen tension and saturation after rectal ozone. This study has a potential clinical significance. AIM The aim of this study was to investigate the effect of rectal ozone on portal vein oxygenation and the pharmacokinetic changes of propranolol in patients with liver cirrhosis. METHODS Fifteen patients with liver cirrhosis were included They were given a fixed oral dose of propranolol 80mg on the morning of day 1 after overnight fasting. Blood samples were collected at fixed time intervals for 24h. Patients were given 12 sessions of rectal ozone of 300ml of 40% ozone/oxygen mixture. On day 14 another oral dose of 80mg propranolol was given and blood samples were collected as on day 1. Plasma concentrations of propranolol were measured by HPLC. Portal vein oxygen tension and saturation were measured before and after rectal ozone. RESULTS Plasma concentrations of propranolol were reduced after ozone therapy with pronounced decreases in the maximum plasma concentration and the area under the plasma concentration-time curve. The changes were consistent with a decrease in propranolol bioavailability. There was a decrease in the elimination half-life and mean residence time. Portal vein oxygenation significantly increased after rectal ozone. CONCLUSIONS The changes in the pharmacokinetics of propranolol probably reflect an increase in the rate and extent of its metabolism resulting from improved portal vein oxygenation attributable to the ozone therapy. The present work highlights that ozone can be an alternative medical measure to improve portal vein oxygenation in liver cirrhosis.

Publication

British Journal of Clinical Pharmacology

Volume

71

Issue

3

Pages

411-415

Date

Mar 2011

Journal Abbr

Br J Clin Pharmacol

DOI

10.1111/j.1365-2125.2010.03851.x

ISSN

1365-2125

URL

http://www.ncbi.nlm.nih.gov/pubmed/21284700

Accessed

2011-02-03 14:04:38

Library Catalog

NCBI PubMed

Extra

PMID: 21284700

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30 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

[The changes of inherent immunity indices and ozonotherapy immunotropic effect in comparison with traditional treatment of patients having type 2 diabetes complicated by pus -necrotic lesions of lower extremities]

Author

Gazin, I K

Author

Istomin, NP

Publication

Immunologiya

Issue

3

Pages

176-177

Date

2008

Journal Abbr

Immunologiya

Language

Russian

ISSN

0206-4952

URL

http://www.medlit.ru/medeng/imm/imm08e.htm

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