30 Enero 2015
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gregorcuba

Item Type

Journal Article

Title

Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C

Author

Zaky, Saad

Author

Kamel, Sherif Ebrahiem

Author

Hassan, Magda Shahata

Author

Sallam, Nadia Abdel

Author

Shahata, Mohamad Ahmad

Author

Helal, Shaaban Redwan

Author

Mahmoud, Heba

Abstract

BACKGROUND Medical ozone is more bactericidal, fungicidal, and virucidal than any other natural substance. Some studies proved that ozone infused into donated blood samples can kill viruses 100% of the time. Ozone, because of its special biologic properties, has theoretical and practical attributes to make it a potent hepatitis C virus (HCV) inactivator, which suggests an important role in the therapy for hepatitis C. AIM The study aim is to evaluate the role of ozone therapy in decreasing HCV ribonucleic acid (HCV RNA) load and its effect on the liver enzymes among patients with chronic hepatitis C. METHODS This study included 52 patients with chronic hepatitis C (positive polymerase chain reaction [PCR] for HCV RNA and raised serum alanine transaminase [ALT] for more than 6 months). All patients were subjected to meticulous history taking and clinical examination. Complete blood count, liver function tests, and abdominal ultrasonography were requested for all patients. The ozone group included 40 patients who received major autohemotherapy, minor autohemotherapy, and rectal ozone insufflation. The other 12 patients (conventional group) received silymarin and/or multivitamins. RESULTS There were significant improvements of most of the presenting symptoms of the patients in the ozone group in comparison to the conventional group. ALT and aspartate transaminase (AST) levels normalized in 57.5% and 60% in the ozone group, respectively, in comparison to 16.7% and 8% in the conventional group, respectively. Polymerase chain reaction (PCR) for HCV RNA was negative among 25% and 44.4% after 30 and 60 sessions of ozone therapy, respectively, in comparison to 8% among the conventional group. CONCLUSIONS Ozone therapy significantly improves the clinical symptoms associated with chronic hepatitis C and is associated with normalized ALT and AST levels among a significant number of patients. Ozone therapy is associated with disappearance of HCV RNA from the serum (-ve PCR for HCV RNA) in 25%-45% of patients with chronic hepatitis C.

Publication

Journal of Alternative and Complementary Medicine (New York, N.Y.)

Volume

17

Issue

3

Pages

259-263

Date

Mar 2011

Journal Abbr

J Altern Complement Med

DOI

10.1089/acm.2010.0016

ISSN

1557-7708

URL

http://www.ncbi.nlm.nih.gov/pubmed/21417811

Accessed

2011-05-10 18:43:55

Library Catalog

NCBI PubMed

Extra

PMID: 21417811

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30 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

[Ozonotherapy in complex treatment in acute calculous cholecystitis]

Author

Gadzhiyev, J N

Author

Amirov, A S

Author

Gadzhiyev, N J

Abstract

The analysis of results of surgical treatment acute calculous a cholecystitis is lead by a traditional method. Patients have been divided into 2 groups. In I group have come 30 sick transferred chlolecystectomy both received standard preoperative and postoperational conservative therapy. 30 patients of II group up to and in the postoperative period in addition intravenously appointed ozonized physiological solution (OPS) with concentration of ozone of 2,5-5 mg / ½ depending on weight of a condition during 3-5 days. The patient with a mechanical jaundice and cholangitis alongside with system ozonotherapy daily during 7-10 days carried out also drop washing choledochus with speed of 50-60 drops in one minute through a drainage tube about 100-150 ml OPS. At all patients before operation, for 1-3, 5-7 day after operation and at an extract studied in blood hydroperoxide lipids, dien conjugates, malonic dialdehyde, catalase and averagemolecular peptide. The received data have shown, that application of medical ozone stabilizing lipoperoxide processes strengthens antioxidant the status of an organism, stoping a sharp inflammation in hepatobiliary to system and by that, enables to lower percent of postoperative pyoinflammatory complications from 16,7 % to 6,7 %. Key words: acute calculous a cholecystitis, peroxide oxidation lipide, ozonotherapy.

Publication

Ukrainskii Zhurnal Khirurgii

Issue

1

Pages

23-31

Date

2009

Journal Abbr

Ukr Zh Khir

Language

Russian

ISSN

1997-2938

URL

http://www.ujs.dsmu.edu.ua/journals/2009-01/01_2009.pdf

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30 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

Ozone Therapy in Patients with Viral Hepatitis C: Ten Years' Experience

Author

Mawsouf, M.N.

Author

Tanbouli, T.T.

Author

Viebahn-Hänsler, R.

Abstract

Hepatitis C is a medical problem in Egypt. The usual line of treatment is very expensive, with major side effects and low efficacy especially in genotype 4, which is common in Egypt. Several studies were performed between 1999 and 2008 to evaluate the role of ozone therapy in HCV (Hepatitis C). The first study included 60 genotype 4 Hepatitis C patients, who received combined ozone treatment with major autohemotherapy three times per week for 8 weeks, followed by twice per week for 16 weeks. It was found that, following 8 weeks of ozone therapy, the viral load decreased in 91.67% of the cases attaining negative PCR in 20%. Following 24 weeks of ozone therapy, there was a further decrease in viral load reaching 95% of the cases, with a negative PCR level in 36.67%. After 8 weeks of ozone therapy, the abnormal enzyme levels were back to normal in 21.67% of the cases for the SGPT enzyme, and were back to normal in 20% for the SGOT enzyme. A second study included 50 genotype 4 Hepatitis C patients. The number of visits was three times per week for 12 weeks followed by twice per week for 12 weeks. The general condition improved in 94% of the cases. There was a decrease in quantitative PCR in 71.8% of the cases that reached negative PCR in 24% after 8 weeks' treatment. The number of negative PCR cases for HCV virus increased to cover 36% of the cases after 24 weeks' treatment. There was a statistically significant improvement as regards the parameters of SGOT, SGPT, albumin, bilirubin and prothrombin after 8 weeks from the start of the study. A third study was carried out on 30 HCV patients, yielding results similar to the previous two.

Publication

Ozone: Science & Engineering

Volume

34

Issue

6

Pages

451-458

Date

2012

DOI

10.1080/01919512.2012.720161

ISSN

0191-9512

Short Title

Ozone Therapy in Patients with Viral Hepatitis C

URL

http://www.tandfonline.com/doi/abs/10.1080/01919512.2012.720161

Accessed

2013-07-04 12:31:53

Library Catalog

Taylor and Francis+NEJM

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