31 Enero 2015
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gregorcuba

Item Type

Journal Article

Title

[Ultrasonic cavitation and ozonization in treatment of patients with pyo-necrotic complications of diabetic foot syndrome]

Author

Zubarev, P N

Author

Risman, B V

Abstract

The main group consisted of 130 patients with pyo-necrotic complications of diabetic foot syndrome, in who after operations within the foot limits, there were ultrasonic cavitation and ozonization of the wound surface. The control group consisted of 90 patients who underwent operative treatment as well as a standard local treatment using the preparations with reference to the phase of the wound process. The use of low-frequency ultrasound allows in short-terms ablation of necrotized tissues within the limits of healthy tissues, decrease of microbial contamination of the wounds and preparing to closing. Ozonization of the wounds facilitates growth of the granulating tissues and prolongs the effect of decontamination of the wound surface. The application of physical methods in treatment of patients with pyo-necrotic complications of diabetic foot syndrome decreases the number of disabling operations.

Publication

Vestnik Khirurgii Imeni I. I. Grekova

Volume

170

Issue

1

Pages

48-53

Date

2011

Journal Abbr

Vestn. Khir. Im. I. I. Grek.

ISSN

0042-4625

URL

http://www.ncbi.nlm.nih.gov/pubmed/21506355

Accessed

2011-12-13 07:46:13

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NCBI PubMed

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PMID: 21506355

 

 

31 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

[Ulcers Treated with Ozone and Growth Factors]

Author

Faus-Vitoria, J.

Abstract

The use of ozone to heal wounds and ulcers dates back to the First World War when it was applied to septic wounds and abscesses which healed better under the disinfectant action of ozone. Between 40 and 50% of patients with diabetes have foot ulcers, leading to amputation in 20% irrespective of the type of ulcer. Ozone therapy is an alternative to amputation given its local and systemic antibacterial and antiviral properties due to the formation of peroxide. Ozone improves cell metabolism due to increased consumption of glucose, fatty acids and aminoacids and activation of free antiradical enzymes.

Publication

Rivista Italiana di Ossigeno-Ozonoterapia

Volume

5

Issue

1

Pages

41–46

Date

2006

Journal Abbr

Riv Ital Ossigeno-Ozonoterapia

Language

English

ISSN

1720-6561

Short Title

El Ozono y los factores de crecimiento en la curación de las ulceras

URL

 

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31 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

Therapeutic effects of topical application of ozone on acute cutaneous wound healing

Author

Kim, Hee Su

Author

Noh, Sun Up

Author

Han, Ye Won

Author

Kim, Kyoung Moon

Author

Kang, Hoon

Author

Kim, Hyung Ok

Author

Park, Young Min

Abstract

This study was undertaken to evaluate the therapeutic effects of topical ozonated olive oil on acute cutaneous wound healing in a guinea pig model and also to elucidate its therapeutic mechanism. After creating full-thickness skin wounds on the backs of guinea pigs by using a 6 mm punch biopsy, we examined the wound healing effect of topically applied ozonated olive oil (ozone group), as compared to the pure olive oil (oil group) and non-treatment (control group). The ozone group of guinea pig had a significantly smaller wound size and a residual wound area than the oil group, on days 5 (P<0.05) and 7 (P<0.01 and P<0.05) after wound surgery, respectively. Both hematoxylin-eosin staining and Masson-trichrome staining revealed an increased intensity of collagen fibers and a greater number of fibroblasts in the ozone group than that in the oil group on day 7. Immunohistochemical staining demonstrated upregulation of platelet derived growth factor (PDGF), transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) expressions, but not fibroblast growth factor expression in the ozone group on day 7, as compared with the oil group. In conclusion, these results demonstrate that topical application of ozonated olive oil can accelerate acute cutaneous wound repair in a guinea pig in association with the increased expression of PDGF, TGF-beta, and VEGF.

Publication

Journal of Korean Medical Science

Volume

24

Issue

3

Pages

368-374

Date

Jun 2009

Journal Abbr

J. Korean Med. Sci

DOI

10.3346/jkms.2009.24.3.368

ISSN

1598-6357

URL

http://www.ncbi.nlm.nih.gov/pubmed/19543419

Accessed

2010-02-24 16:46:29

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NCBI PubMed

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PMID: 19543419

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