31 Enero 2015
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Item Type

Journal Article

Title

The orthodox therapy of cardiovascular diseases integrated by ozone-therapy is able to normalize the redox system

Author

Bocci, Velio

Author

Borrelli, Emma

Author

Zanardi, Iacopo

Author

Travagli, Valter

Abstract

Cardiovascular diseases such as chronic limb ischemia, cardiomyopathies and stroke represent the first cause of death. Moreover, type-II diabetes, chronic obstructive pulmonary disease and age-related macular degeneration are also progressive pathologies complicated by a chronic inflammation that might be able to maintain progressive chronic oxidative stress. Orthodox medicine has provided excellent drugs which slow down the progression of these diseases but minimally reverse the oxidative stress conditions. Administration of antioxidants is unable to balance the oxidant excess. Today, all the biochemical and molecular mechanisms of ozone therapy have been clarified and it has been demonstrated that ozone therapy can reactivate the fundamental Nrf2 system and be able to restore the innate antioxidant defense mechanisms composed of several highly protective enzymes. This paper proposes to integrate the orthodox treatment with ozone therapy for improving clinical results. KEYWORDS Chronic Oxidative Stress; Ozone-Therapy; Nrf2-Keap1; Antioxidant Response; Integrative Medicine

Publication

World Journal of Cardiovascular Diseases World Journal of Cardiovascular Diseases

Volume

3

Issue

3

Pages

308-311

Date

2013

Journal Abbr

World J Cardiovasc Dis

Language

English

ISSN

2164-5329 (Print), 2164-5337 (Oline)

URL

http://www.scirp.org/journal/PaperInformation.aspx?paperID=33359#.UzgVzlf5Jxc

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31 Enero 2015
Administrator

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Item Type

Journal Article

Title

[The influence of ozone therapy on endothelial damage markers in patients with atherosclerosis of lower extremities]

Author

Rość, D

Author

Ponikowska, I

Author

Paczuski, R

Author

Włodarczyk, K

Author

Zastawna, E

Author

Michalski, A

Abstract

The aim of study was to evaluate the influence of the treatment with oxygen-ozone mixture on the blood plasma antigen concentration of tissue plasminogen activator (t-PA) and von Willebrand factor (vWF) in patients suffering from atherosclerotic disease of lower extremities. The study was performed in the group of 28 (M/F 22/6) patients means aged 64.1 years with atherosclerotic diseases of lower extremities, in whom 2 weeks therapy with oxygen-ozone mixture was used. The control group consisted of 30 healthy volunteers in mean age 51.0 years. In the blood plasma obtained from the patients before and after treatment with oxygen-ozone mixture and from the control group determinations of t-PA and vWF antigen using ELISA were done. Both parameters were significantly increased in the patients before the treatment in comparison to the healthy controls. The treatment with oxygen-ozone therapy caused in patients slight statistically not significant raise of t-PA and vWF antigen showing the endothelial stimulation but not the destruction of vascular endothelium.

Publication

Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego

Volume

6

Issue

33

Pages

135-137

Date

Mar 1999

Journal Abbr

Pol. Merkur. Lekarski

ISSN

1426-9686

URL

http://www.ncbi.nlm.nih.gov/pubmed/10365597

Accessed

2010-02-18 17:00:44

Library Catalog

NCBI PubMed

Extra

PMID: 10365597

 

 

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31 Enero 2015
Administrator

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Item Type

Journal Article

Title

The influence of ozonated autohemotherapy on oxidative stress in hemodialyzed patients with atherosclerotic ischemia of lower limbs

Author

Tylicki, L

Author

Nieweglowski, T

Author

Biedunkiewicz, B

Author

Chamenia, A

Author

Debska-Slizien, A

Author

Aleksandrowicz, E

Author

Lysiak-Szydlowska, W

Author

Rutkowski, B

Abstract

Ozonated autohemotherapy is used as a complementary medical approach in the treatment of vascular disorders. One of the greatest problems concerning an application of ozone in medicine is its induction of oxidative stress. The standards of ozonotherapy were elaborated recently making this treatment useful and probably non toxic. The aim of the present study was to investigate the influence of ozonated autohemotherapy on the oxidative stress extent in hemodialyzed patients, known to be particularly exposed to generation and deleterious effects of free radicals. Twelve continuously hemodialyzed subjects with atherosclerotic ischemia of the lower limbs were examined in a prospective, controlled, single blind study. Autohemotherapy with blood exposure to oxygen served as a control. The protein and lipid peroxidation products, the reduced glutathione level in red blood cells and free hemoglobin plasma concentration were measured. The study showed that ozonated autohemotherapy with ozone concentration 50 microg/ml per gram of blood induced a significant decrease in glutathione level after 9 sessions of this procedure. Therapy did not cause either the enhancement of protein and lipid peroxidation, or erythrocytes damage. It seems likely that the antioxidant defense system, part of which is glutathione, neutralizes oxidative properties of ozone in this concentration and protects against oxidative cell damage.

Publication

International Journal of Artificial Organs

Volume

26

Issue

4

Pages

297-303

Date

2003

Journal Abbr

Int J Artif Organs

Language

English

ISSN

0391-3988 (Print)

URL

http://www.ncbi.nlm.nih.gov/pubmed/12757028

Extra

PMID: 12757028

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