31 Enero 2015
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Item Type

Conference Paper

Title

Ozono: patofisiología vascular e investigaciones en curso. [Ozone: vascular pathophysiology and current research].

Author

Clavo, Bernardino

Author

Santana-Rodríguez, Norberto

Author

Llontop, Pedro

Author

Méndez, Charlin

Author

Suárez, Gerardo

Author

Gutiérrez, Dominga

Author

Jorge, Ignacio

Author

Cabezón, Auxiliadora

Author

Fiuza, Dolores

Author

Robaina, Francisco

Date

2011/ 10 / 7

Conference Name

III. Iberoamerican Congress of Oxygen- Ozonetherapy. II. Brazilian Congress of Ozonetherapy. I. Brazilian Congress of Hydro- Ozonetherapy

Place

Rio de Janeiro (Brazil)

Language

Spanish

URL

 

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31 Enero 2015
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Item Type

Journal Article

Title

Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissue in patients with peripheral occlusive arterial disease

Author

Giunta, R

Author

Coppola, A

Author

Luongo, C

Author

Sammartino, A

Author

Guastafierro, S

Author

Grassia, A

Author

Giunta, L

Author

Mascolo, L

Author

Tirelli, A

Author

Coppola, L

Abstract

Twenty-seven subjects suffering from peripheral occlusive arterial disease (POAD, clinical stage II-III according to Fontaine) were enrolled in this study to evaluate the effect of oxygen-ozone therapy upon hemorheological parameters and hemoglobin-oxygen affinity in patients with POAD. All patients underwent a major ozonized autohemotransfusion consisting of the slow reinfusion of 100 ml of autologous blood, previously exposed to a O(2)-O(3) mixture in a glass box for 10 min. Whole blood viscosity, erythrocyte filterability, hematocrit, and fibrinogen levels were assessed at the basal time and 30 min after the reinfusion of ozonized blood. At the same time p50 standard (p50std) values (an indicator of hemoglobin-oxygen affinity) and plasma values of malonyl dialdehyde (MDA, an indicator of lipid peroxidation) were evaluated. At the baseline, patients had significantly higher ( p<0.05- p<0.001) whole blood viscosity, MDA, and p50std values and significantly lower blood filterability ( p<0.01) as compared with 20 matched healthy volunteers (controls). Thirty minutes after the end of a major autohemotransfusion, whole blood viscosity significantly decreased ( p<0.01). This was accompanied by a significant fall in plasma fibrinogen level ( p<0.01) with no change in hematocrit. Blood filterability, MDA plasma level, and p50std values increased significantly at the same time ( p<0.01- p<0.005). The 2,3-DPG value did not change significantly. No significant changes occurred when the same patients received a non-ozonized autohemotransfusion (control test). In conclusion, ozonized autohemotransfusion may be useful to improve both the poor rheological properties of the blood and the oxygen delivery to tissues in patients suffering from POAD.

Publication

Annals of Hematology

Volume

80

Issue

12

Pages

745-748

Date

2001

Journal Abbr

Ann Hematol

Language

English

ISSN

0939-5555 (Print), 1432-0584 (Electronic)

URL

http://www.springerlink.com/content/100397/

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31 Enero 2015
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gregorcuba

Item Type

Journal Article

Title

Ozonized autohaemotransfusion and fibrinolytic balance in peripheral arterial occlusive disease

Author

Coppola, L

Author

Lettieri, B

Author

Cozzolino, D

Author

Luongo, C

Author

Sammartino, A

Author

Guastafierro, S

Author

Coppola, A

Author

Mastrolorenzo, L

Author

Gombos, G

Abstract

The acute effects of a major ozonized autohaemotransfusion on blood fibrinolytic capacity were evaluated in 20 subjects affected by peripheral arterial occlusive disease (PAOD). The parameters examined were tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type-1 (PAI-1). In subjects not previously submitted to autohaemotransfusion ('unaccustomed' subjects), whether they were PAOD patients or healthy volunteers, the PAI-1/t-PA ratio in the blood samples taken 15 min before the autohaemotransfusion was higher (P < or = 0.05) than at baseline. These changes were independent of the presence of ozone in the autohaemotransfusion blood. Values in both healthy and PAOD-affected individuals were again at baseline 120 min after the end of autohaemotransfusion. In PAOD patients and in healthy subjects previously submitted to several autohaemotransfusions ('accustomed' subjects), the PAI-1/t-PA ratio did not significantly change before, during and after an additional autohaemotransfusion. The results (the increased heart rate and epinephrine and norepinephrine urinary excretion only in non-accustomed subjects) suggest that the acute fibrinolytic imbalance is caused by the apprehensive state produced by the procedure in unaccustomed subjects. Autohaemotransfusion with ozonized blood per se does not significantly influence the fibrinolytic balance.

Publication

Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis

Volume

13

Issue

8

Pages

671-681

Date

Dec 2002

Journal Abbr

Blood Coagul. Fibrinolysis

ISSN

0957-5235

URL

http://www.ncbi.nlm.nih.gov/pubmed/12441905

Accessed

2010-07-27 17:31:04

Library Catalog

NCBI PubMed

Extra

PMID: 12441905

 

 

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