31 Enero 2015
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Item Type

Journal Article

Title

[Arteriosclerosis obliterans and ozone therapy. Its administration by different routes]

Author

Romero Valdés, A

Author

Blanco González, R

Author

Menéndez Cepero, S

Author

Gómez Moraleda, M

Author

Ley Pozo, J

Abstract

We report 72 non-diabetic patients with obliterant atherosclerosis, stadium II, (intermittent claudication). The medium age of these patients was 62 +/- 4.5 years old. They were randomly included into four groups. Three were treated with Ozone: one of them by endovenous way, other intramuscular way, and the last one by rectal way; meanwhile, in the fourth group the patients were submitted to conventional medical treatment (control group). In the three ozone-groups there weren't differences when they were compared between then. But there was a significant improvement in comparison with the control group. The claudication distance in the treadmill increased to the 2.5 km/hour. Ankle/arm pressure rates hadn't significant differences, this corroborates the ozone action on the microcirculation. The least uncomfortable, the more harmless and the more economic way was the rectal way.

Publication

Angiología

Volume

45

Issue

5

Pages

177-179

Date

1993 Sep-Oct

Journal Abbr

Angiologia

ISSN

0003-3170

URL

http://www.ncbi.nlm.nih.gov/pubmed/8285365

Accessed

2010-02-18 17:00:18

Library Catalog

NCBI PubMed

Extra

PMID: 8285365

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31 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

[Arterial occlusive disease: Pharmacological therapy and ozone therapy]

Author

Colombo, R

Author

D'Angelo, F

Author

Arzini, A

Author

Abbritti, F

Author

Boccalon, L

Abstract

Background: The therapeutic effects of intravenous ozone in the treatment of arterial occlusive disease have been known for some time. Various authors have shown how this treatment improves the transport and release of oxygen to tissues. Methods: Among the main mechanisms underlying this result, the most important is increased 2,3 diphosphoglycerate (2,3 DPG). This enzyme results in a diminished affinity of the hemoglobin for oxygen, thereby enabling the latter's increased release to the tissues. Results: We compared the results in a sample of patients receiving conventional pharmacological therapy and a group of patients receiving ozone therapy according to our usual protocols. All the patients were treated using a major own-blood transfusion. The dose used for every transfusion was 5000 ng ozone added to 200 cc uncoagulated blood with citrate. Applications were continued twice weekly for a total of 5 sessions. A total of 50 pharmacologically-treated patients were included at Fontaine's second stage. Another group of 50 patients commenced ozone treatment at the same time. Patients receiving pharmacological treatment presented improved symptoms in 50% of cases. Those who were treated with ozone treatment showed improved symptoms in 86% of cases. Changes in 2,3 DPG evaluated before and after treatment were correlated with the improved symptoms achieved. In general low indices of 2,3 DPG corresponded to enhanced levels after treatment and improved symptoms. However, significant improvements were noted even in the event of high enzyme levels before treatment. Conclusions: The predictive criterion for cases with low indices of 2,3 DPG at the start of treatment is indicative and not absolute. Ozone activity induces improvements that exceed all expectations when the patients to be treated present a metabolic reserve requiring stimulation and strengthening.

Publication

Gazzetta Medica Italiana Archivio per le Scienze Mediche

Volume

159

Issue

2

Pages

53-57

Date

2000

Journal Abbr

Gazz Med Ital Arch Sci Med

Language

Italian

ISSN

0393-3660

URL

 

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