03 Febrero 2015
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gregorcuba

Item Type

Journal Article

Title

The evaluation of ozone and betahistine in the treatment of tinnitus

Author

Sönmez, Onur

Author

Külahlı, Ismail

Author

Vural, Alperen

Author

Sahin, Mehmet Ilhan

Author

Aydın, Mesut

Abstract

The aim of the study is to evaluate the effectiveness of ozone and betahistine treatments in the treatment of tinnitus. Sixty-eight patients were enrolled in this randomized, prospective controlled study. The ozone group consisted of 27, betahistine group consisted of 26 and control group consisted of 15 patients. The patients in ozone group received 10 sessions of ozone treatment via major autohemotherapy. Betahistine group received 48 mg/day betahistine tablets per oral for 3 months duration. The control group was followed up without any treatment given. The evaluation of tinnitus was made by tinnitus loudness and tinnitus handicap inventory (THI). The changes in findings from baseline to 3rd and 6th months were assessed, and the group results were compared. Comparison of the initial mean tinnitus loudness and 3 and 6 months after treatment in each of the three groups did not reveal a significant difference. The comparison between the groups in terms of the improvement of tinnitus loudness was not significant (p = 0.821). Comparison of the initial mean THI and 3 and 6 months after treatment revealed a significant difference in ozone and betahistine groups but not in the control group. When the delta (Δ) THI (the change of mean THI between the initial and 6th month) was compared between the groups, there was no significant difference. This randomized controlled study investigating the effects of ozone in tinnitus tries to shed light to a new method of treatment in tinnitus. The findings of the study does not provide enough evidence to support ozone and betahistine as a treatment for tinnitus and further research on the subject is necessary.

Publication

European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Volume

270

Issue

7

Pages

1999-2006

Date

Jul 2013

Journal Abbr

Eur Arch Otorhinolaryngol

Language

eng

DOI

10.1007/s00405-012-2228-8

ISSN

1434-4726

URL

 

Library Catalog

NCBI PubMed

Extra

PMID: 23100082

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03 Febrero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

[Reasons for the application of medical ozone in the treatment of chronic purulent mesotympanitis]

Author

Shakov, V Iu

Author

Edeleva, A N

Abstract

Ozone-oxygen mixture (ozone concentration 600 microg/l) was used in irrigations of the tympanic cavity in 52 patients with chronic purulent mesotympanitis (CPM). The course of the treatment consisted of 5-7 procedures. 18 CPM controls received standard treatment without the irrigations. The course of the ozone-oxygen irrigations produced good results: ear discharge and tympanic mucosa inflammation stopped in 81% of the irrigated patients, levels of myeloperoxidase which marks inflammation reduced significantly, bactericidal effects of the mixture were observed for all the detected pathogens, antibiotic sensitivity of the bacteria rose. Fast antiinflammatory result of ozone therapy was due not only to its bactericidal effect but also via its antihypoxic and immunomodulating mechanisms.

Publication

Vestnik Otorinolaringologii

Issue

2

Pages

48-49

Date

1999

Journal Abbr

Vestn. Otorinolaringol

ISSN

0042-4668

URL

http://www.ncbi.nlm.nih.gov/pubmed/10226494

Accessed

2010-02-18 22:26:31

Library Catalog

NCBI PubMed

Extra

PMID: 10226494

 

 

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03 Febrero 2015
Administrator

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gregorcuba

Item Type

Journal Article

Title

Randomised, double-blinded, placebo-controlled, clinical trial of ozone therapy as treatment of sudden sensorineural hearing loss

Author

Bocci, V

Author

Travagli, V

Author

Zanardi, I

Publication

The Journal of Laryngology and Otology

Volume

123

Issue

7

Pages

820; author reply 820

Date

Jul 2009

Journal Abbr

J Laryngol Otol

DOI

10.1017/S0022215109005350

ISSN

1748-5460

URL

http://www.ncbi.nlm.nih.gov/pubmed/19379546

Accessed

2010-02-24 19:01:18

Library Catalog

NCBI PubMed

Extra

PMID: 19379546

 

 

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