10 Febrero 2015
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Item Type Journal Article
Title [Therapeutic Response in Children and Adolescents with Myopia that Were Treated with Ozone]
Author Borrego Díaz, Luís
Author Díaz Santos, Elena
Author Sera Valázquez, Surina
Author Batista Hernández, Liliana María
Author Milian Reyes, Marta
Abstract A descriptive study in 25 children and adolescents with myopia, that were assisted at ophthalmology consultation at Provincial Center of Retinitis in 2008 was carried out.Patients were treated with ozone therapy through rectal tract , in spite of they underwent surgery they had symptoms like nyctalopia, blurred vision and inflammatory symptoms of the previous segment, with a half dose of 3 mg daily with 15 applications. In 76 % of patients the improvement of the symptoms was noticed in the first week of treatment, only 4 % of them did not improve in 15 days with therapy. The favourable action with ozone was demonstrated once again for biological response as antiinflammatory as well as in case of hypoxia symptoms. Key words: myopia, ozone therapy, hypoxia.
Publication Correo Científico Médico de Holguín
Volume 12
Issue 4
Date 2008
Journal Abbr Corr Cient Med Holg
Language Spanish
URL http://www.imbiomed.com/1/1/articulos.php?method=showDetail&id_revista=64&id_seccion=2082&id_ejemplar=5517&id_articulo=54434
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10 Febrero 2015
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Added by gregorcuba
Item Type Journal Article
Title Safety of ozonated solution as an antiseptic of the ocular surface prior to ophthalmic surgery
Author Kashiwagi, K
Author Saito, K
Author Wang, Y D
Author Takahashi, H
Author Ishijima, K
Author Tsukahara, S
Abstract PURPOSE: To evaluate the safety of an ozonated solution as an antiseptic of the ocular surface prior to ophthalmic surgery. METHODS: In experiment 1, a primary culture of rabbit corneal epithelium was established. Then, 0, 4 and 10 ppm ozonated solution and 1.25% povidone-iodine, respectively, were applied to confluent cells on collagen-coated filter inserts (Millicell-CM) for 10 min followed by replacement with fresh medium. The transepithelial electrical resistance (TER), which is a good indicator of cell barrier function, was sequentially measured for 30 min. In experiment 2, adult pigmented rabbit eyes were washed with 20 ml of 4 ppm ozonated solution, 1.25% povidone-iodine solution or saline. Slitlamp examinations were performed before and after washing. RESULTS: In experiment 1, 4 ppm ozonated solution did not change the TER as compared with the control. 10 ppm ozonated solution and 1.25% povidone-iodine similarly reduced the TER values significantly as compared with those of the control and 4 ppm ozonated solution. In experiment 2, 4 ppm ozonated solution and saline showed mild superficial punctate keratitis (SPK) in 8.3% of eyes. However, 1.25% povidone-iodine resulted in mild SPK in 17% of eyes and moderate SPK in 25% of eyes. The prevalence of SPK between two groups was significantly different (p = 0.03). CONCLUSION: Ozonated solution may be safe and a useful antiseptic of the ocular surface prior to ophthalmic surgery.
Publication Ophthalmologica. Journal International D'ophtalmologie. International Journal of Ophthalmology. Zeitschrift Für Augenheilkunde
Volume 215
Issue 5
Pages 351-356
Date 2001 Sep-Oct
Journal Abbr Ophthalmologica
ISSN 0030-3755
URL http://www.ncbi.nlm.nih.gov/pubmed/11528260
Accessed 2010-02-20 21:22:40
Library Catalog NCBI PubMed
Extra PMID: 11528260
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10 Febrero 2015
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Retinitis Pigmentosa patients treated with ozone therapy during 20 years. Cuban experiences.

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Item Type Web Page
Title Retinitis Pigmentosa patients treated with ozone therapy during 20 years. Cuban experiences.
Author Menéndez Cepero, Silvia
Author Copello, Mirta
Abstract Retinitis Pigmentosa (RP) is characterized by bad night vision, decrease of visual field and/or acuity, with electroretinogram (ERG) diminished in amplitude and finally, non reproducible. Taking into account some of the ozone biological effects, as: improvement in the oxygen metabolism, increase in the cell energy, the immunomodulator capacity and enhancement of the antioxidant defense system the aim of this paper is to assess ozone therapy’s efficacy in these patients, treated twice a year during 20 years. A controlled and retrospective clinical study was performed in 56 patients with Typical Retinitis Pigmentosa (non-associated), with sample homogeneity, in age, sex and stage of the disease, and with signed informed consent. Forty patients received ozone daily, by rectal way, during 20 sessions (at a concentration of 40 mg/L and a volume of 200 mL) as only treatment, with repetition of this cycle every 6 months, and 16 received other medical treatments (control group). Results showed that, after 10 years, patients in stages I and II had a better response to ozone therapy, and this response was more lasting, with an improvement attained as of 4 months, which is the shortest time period for patients in stages II and IV. After 20 years of treatment, 50.1 % of patients improved their visual field, 31.1 % remained the same and 18 % followed the course of the disease. In respect to visual acuity, we observed that 37.5% of patients improved, 34.9 % remained stable and 27.6 % continued the course of the disease. It is recommended to apply ozone therapy at six-month intervals in order to delay the course of the disease and maintain the visual capabilities. No side effects were observed. Ozone therapy is a good therapeutic choice in the treatment of patients with RP increasing their quality of life.
Website Title Revista Española de Ozonoterapia
Website Type Text.Serial.Journal
Date 2011-05-25
URL http://www.revistaespañoladeozonoterapia.es/index.php/reo/article/view/3/15
Accessed 2011-06-12 08:22:58
Language English
Rights Los autores conservan los derechos de autor y garantizan a Revista Española de Ozonoterapia el derecho de ser la primera publicación del trabajo al igual que licenciado bajo una Creative Commons Attribution License que permite a otros compartir el trabajo con un reconocimiento de la autoría del trabajo y la publicación inicial en esta revista. El uso de los trabajos no debe implicar intereses comerciales y se deberán compartir bajo licencia Creative Commons. Declaración de privacidad Los nombres y direcciones de correo electrónico introducidos en esta revista se usarán exclusivamente para los fines declarados y no estarán disponibles para ningún otro propósito u otra persona.
Extra Retinitis Pigmentosa (RP) is characterized by bad night vision, decrease of visual field and/or acuity, with electroretinogram (ERG) diminished in amplitude and finally, non reproducible. Taking into account some of the ozone biological effects, as: improvement in the oxygen metabolism,  increase in the cell energy, the immunomodulator capacity and enhancement of the antioxidant defense system the aim of this paper is to assess ozone therapy’s efficacy in these patients, treated twice a year during 20 years. A controlled and retrospective clinical study was performed in 56 patients with Typical Retinitis Pigmentosa (non-associated), with sample homogeneity, in age, sex and stage of the disease, and with signed informed consent. Forty patients received ozone daily, by rectal way, during 20 sessions (at a concentration of 40 mg/L and a volume of 200 mL) as only treatment, with repetition of this cycle every 6 months, and 16 received other medical treatments (control group). Results showed that, after 10 years, patients in stages I and II had a better response to ozone therapy, and this response was more lasting, with an improvement attained as of 4 months, which is the shortest time period for patients in stages II and IV. After 20 years of treatment, 50.1 % of patients improved their visual field, 31.1 % remained the same and 18 % followed the course of the disease. In respect to visual acuity, we observed that 37.5% of patients improved, 34.9 % remained stable and 27.6 % continued the course of the disease. It is recommended to apply ozone therapy at six-month intervals in order to delay the course of the disease and maintain the visual capabilities. No side effects were observed. Ozone therapy is a good therapeutic choice in the treatment of patients with RP increasing their quality of life.
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