Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C

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en 06 Febrero 2015

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Item Type

Journal Article

Title

Preliminary results of ozone therapy as a possible treatment for patients with chronic hepatitis C

Author

Zaky, Saad

Author

Kamel, Sherif Ebrahiem

Author

Hassan, Magda Shahata

Author

Sallam, Nadia Abdel

Author

Shahata, Mohamad Ahmad

Author

Helal, Shaaban Redwan

Author

Mahmoud, Heba

Abstract

BACKGROUND Medical ozone is more bactericidal, fungicidal, and virucidal than any other natural substance. Some studies proved that ozone infused into donated blood samples can kill viruses 100% of the time. Ozone, because of its special biologic properties, has theoretical and practical attributes to make it a potent hepatitis C virus (HCV) inactivator, which suggests an important role in the therapy for hepatitis C. AIM The study aim is to evaluate the role of ozone therapy in decreasing HCV ribonucleic acid (HCV RNA) load and its effect on the liver enzymes among patients with chronic hepatitis C. METHODS This study included 52 patients with chronic hepatitis C (positive polymerase chain reaction [PCR] for HCV RNA and raised serum alanine transaminase [ALT] for more than 6 months).  

All patients were subjected to meticulous history taking and clinical examination. Complete blood count, liver function tests, and abdominal ultrasonography were requested for all patients. The ozone group included 40 patients who received major autohemotherapy, minor autohemotherapy, and rectal ozone insufflation. The other 12 patients (conventional group) received silymarin and/or multivitamins. RESULTS There were significant improvements of most of the presenting symptoms of the patients in the ozone group in comparison to the conventional group. ALT and aspartate transaminase (AST) levels normalized in 57.5% and 60% in the ozone group, respectively, in comparison to 16.7% and 8% in the conventional group, respectively. Polymerase chain reaction (PCR) for HCV RNA was negative among 25% and 44.4% after 30 and 60 sessions of ozone therapy, respectively, in comparison to 8% among the conventional group. CONCLUSIONS Ozone therapy significantly improves the clinical symptoms associated with chronic hepatitis C and is associated with normalized ALT and AST levels among a significant number of patients. Ozone therapy is associated with disappearance of HCV RNA from the serum (-ve PCR for HCV RNA) in 25%-45% of patients with chronic hepatitis C.

Publication

Journal of Alternative and Complementary Medicine (New York, N.Y.)

Volume

17

Issue

3

Pages

259-263

Date

Mar 2011

Journal Abbr

J Altern Complement Med

DOI

10.1089/acm.2010.0016

ISSN

1557-7708

URL

http://www.ncbi.nlm.nih.gov/pubmed/21417811

Accessed

2011-05-10 18:43:55

Library Catalog

NCBI PubMed

Extra

PMID: 21417811

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