23 Enero 2015
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gregorcuba

Item Type

Journal Article

Title

Natural killer cell activity unaffected by ozonated autohemotherapy in patients with end-stage renal disease on maintenance renal replacement therapy

Author

Biedunkiewicz, B

Author

Tylicki, L

Author

Rachon, D

Author

Hak, L

Author

Nieweglowski, T

Author

Chamienia, A

Author

Debska-Slizien, A

Author

Mysliwska, J

Author

Rutkowski, B

Abstract

Ozonotherapy is a complementary medical approach in the treatment of resistant infections, immune deficiency syndromes, orthopedic pathologies and vascular diseases. The criticism of this method is associated with potentially harmful effects of ozone on cells. The aim of this study was to investigate the influence of ozonated autohemotherapy (O3-AHT) on the cellular response of the immunologic system represented by cytotoxic activity of natural killer cells. 12 hemodialyzed patients (8 M, 4 F) aged 64.8 +/- 7.6 years with peripheral arterial disease as the main reason for the treatment with O3-AHT were examined in a prospective, placebo controlled, single blind study. They received 9 sessions of autohemotherapy without ozone exposure as a placebo-control and subsequent 9 sessions of O3-AHT. The procedures were performed 3 times a week, just before hemodialysis session. Ozone-oxygen gas mixture with ozone concentration of 50 microg/ml produced by ozone generator (ATO3, KrioMetrum, Poland) was used during O3-AHT Natural killer cell activity was measured using lactate dehydrogenase release assay There was no statistical difference between natural killer cell activity (%) at the baseline (16.78 +/- 8.07), after nine sessions of control autohemotherapy (15.98 +/- 6.67), and after nine sessions of O3-AHT (18.26 +/- 8.82). In conclusion, our findings showed that O3-AHT in a dose of 50 mg/mL does not have any significant influence on natural killer cell function in hemodialyzed patients.

Publication

The International Journal of Artificial Organs

Volume

27

Issue

9

Pages

766-771

Date

Sep 2004

Journal Abbr

Int J Artif Organs

ISSN

0391-3988

URL

http://www.ncbi.nlm.nih.gov/pubmed/15521216

Accessed

2010-02-24 16:38:32

Library Catalog

NCBI PubMed

Extra

PMID: 15521216

 

 

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23 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

Microcirculation and Structural Reorganization of the Bladder Mucosa in Chronic Cystitis under Conditions of Ozone Therapy

Author

Neimark, A. I.

Author

Nepomnyashchikh, L. M.

Author

Lushnikova, E. L.

Author

Bakarev, M. A.

Author

Abdullaev, N. A.

Author

Sizov, K. A.

Abstract

Structural reorganization of the bladder mucosa in chronic cystitis and its correction by ozone therapy were studied. A relationship between the epithelial layer restructuring of different kinds (dystrophy, metaplasia, and degeneration), level of cell proliferation, and ultrastructural organization of urotheliocytes was detected. This complex of structural reactions was combined with dysregulation of tissue bloodflow in the bladder mucosa, shown by laser Doppler flowmetry. Positive structural changes were most marked in intravesical and less so in parenteral ozone therapy added to the therapeutic complex and manifested in reduction of inflammation and alteration in parallel with more intense reparative reactions. A special feature of parenteral ozone therapy was a significant improvement of microcirculation in the bladder mucosa.

Publication

Bulletin of Experimental Biology and Medicine

Volume

156

Issue

3

Pages

399-405

Date

2014/01/01

Journal Abbr

Bull Exp Biol Med

Language

English

DOI

10.1007/s10517-014-2358-7

ISSN

0007-4888, 1573-8221

URL

http://link.springer.com/article/10.1007/s10517-014-2358-7

Accessed

2014-02-05 17:02:01

Library Catalog

link.springer.com.ezproxy.uef.fi:2048

 

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23 Enero 2015
Administrator

Added by

gregorcuba

Item Type

Journal Article

Title

Intravesical ozone therapy for progressive radiation-induced hematuria

Author

Clavo, Bernardino

Author

Gutiérrez, Dominga

Author

Martín, Dionisio

Author

Suárez, Gerardo

Author

Hernández, María A

Author

Robaina, Francisco

Abstract

BACKGROUND: Progressive radiation-induced cystitis can become a serious clinical problem the therapeutic solution of which is limited and almost invariably aggressive. Ozone therapy is a nonconventional therapy that has been reported to offer benefits in late-onset wound healing and ischemic disorders. This report describes a patient with progressive radiation-induced hematuria from standard conservative treatment that was further treated with ozone therapy. METHOD: Ozone therapy was achieved by intravesical instillation of ozonized bi-distilled water over a period of 30 minutes, three sessions per week during the first weeks. Later, ozone therapy sessions were decreased and involved ozonized water or direct intravesicular instillation of ozone at 20-25 microg/mL. RESULTS: Hematuria was successfully controlled by intravesical application of ozone therapy. CONCLUSIONS: The successes achieved with this technique suggest that intravesicular instillation of ozonized bi-distilled water or ozone merits further investigation with a view to its application to counter this radiation-induced side-effect.

Publication

Journal of Alternative and Complementary Medicine (New York, N.Y.)

Volume

11

Issue

3

Pages

539-541

Date

Jun 2005

Journal Abbr

J Altern Complement Med

DOI

10.1089/acm.2005.11.539

ISSN

1075-5535

URL

http://www.ncbi.nlm.nih.gov/pubmed/15992242

Accessed

2010-02-19 19:17:51

Library Catalog

NCBI PubMed

Extra

PMID: 15992242

 

 

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