29 Septiembre 2014
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The liver is damaged by sustained ischaemia during liver transplantation, and the reperfusion after ischaemia results in further functional impairment. Ozone oxidative preconditioning (OzoneOP) protected the liver against ischaemia/reperfusion (I/R) injury through different mechanisms. The aim of this study was to investigate the influence of the inhibition of protein synthesis on the protective actions conferred by OzoneOP in hepatic I/R...

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29 Septiembre 2014
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The rectal insuffation of a judicious dose of ozone, selected from that used in clinical practice, is able to promote oxidative preconditioning or oxidative stress tolerance preventing the hepatocellular damage mediated by free radicals...

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29 Septiembre 2014
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Ozone oxidative preconditioning is a prophylactic approach, which favors the antioxidant-prooxidant balance for preservation of cell redox state by the increase of antioxidant endogenous systems in both in vivo and in vitro experimental models. Our aim is to analyze the effect of ozone oxidative preconditioning on serum TNF-? levels and as a modulator of oxidative stress on hepatic tissue in endotoxic shock model (mice treated with lipopolysaccharide (LPS))...

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29 Septiembre 2014
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La sepsis continúa siendo la mayor causa de muerte en muchas de las unidades quirúrgicas de cuidados intensivos; por tanto, aún se continúan desarrollando nuevos modelos experimentales para descifrar esta compleja patogenia y encontrar nuevas formas terapéuticas. En este estudio, se emplearon ratas Wistar mancho (180 a 200g) con el objetivo de evaluar el efecto profiláctico de diferentes concentraciones de ozono en un modelo de choque séptico letal.

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29 Septiembre 2014
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In combination with the most suitable orthodox therapy, there are rational bases for justifying the use of ozone therapy in critical patients. This approach is difficult to implement in intensive care units, not for technical reasons, but because ozone therapy is regarded with suspicion and scepticism. However...

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29 Septiembre 2014
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Oxidative stress is suggested to have an important role in the development of complications in diabetes. Because ozone therapy can activate the antioxidant system, influencing the level of glycemia and some markers of endothelial cell damage, the aim of this study was to investigate the therapeutic efficacy of ozone in the treatment of patients with type 2 diabetes and diabetic feet and to compare ozone with antibiotic therapy...

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29 Septiembre 2014
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In spite of the fact that ozone has been used as a therapeutical agent and beneficial effects have been observed, so far only a few biochemical and pharmacodynamic mechanisms have been studied. We have demonstrated that controlled ozone administration may promote an oxidative preconditioning or adaptation to oxidative stress, preventing the damage induced by Reactive Oxygen Species (ROS) through preservation of antioxidant endogenous systems...

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29 Septiembre 2014
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AUTORES:

SAID MOHAMMED AL-DALAINa, GREGORIO MARTÍNEZa, EDUARDO CANDELARIO-JALILa,
SILVIA MENÉNDEZb, LAMBERTO REc, ATTILIA GIULIANId and OLGA SONIA LEÓNa

aCenter for Research and Biological Evaluation (CIEB-IFAL), University of Havana, Havana 10400,
Cuba, bOzone Research Center, Cuba, cUniversity of Ancona, Italy, dDepartment of Chemistry and
Medical Biochemistry, University of Milan, Via Saldini, 50-20133 Milan, Italy

 

REVISTA O SITIO ELECTRÓNICO (URL) DONDE SE PUBLICO:

Pharmacological Research, Vol. 44, No. 5, 2001. doi:10.1006/phrs.2001.0867, available online at http://www.idealibrary.com on

 

ABSTRACT:

Ozone has been used as a therapeutical agent and beneficial effects have been observed. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. We demonstrate that controlled ozone administration may promote an oxidative preconditioning or adaptation to oxidative stress, preventing the damage induced by reactive oxygen species (ROS).

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29 Septiembre 2014
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This paper describes an innovative method of inactivating blood-borne viruses using ultraviolet blood irradiation called UBI therapy. This process has shown impressive clinical results in treating hepatitis, HIV, and other currently untreatable viruses. The background, theory, and method of using UBI therapy is presented in this paper. This method offers a potential break-through in the treatment of viral diseases and bacteria, and is nontoxic, uses no drugs, and even has FDA certification, and thus is available now for use.

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29 Septiembre 2014
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Ozone is a very reactive gas that is toxic to the respiratoy system. However, under controlled conditions, it can be therapeutically useful in several human diseases. An unfavourable combination of factors (ozone is one of the worst troposphere pollutants) and past minuse have led to misgiving about ozonetherapy. However, basic and clinical work developed over the past 10 years has clarified the fundamental mechanisms of action of ozone in biology and medicine...

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