29 Septiembre 2014
Administrator

Redox environment involves a broad network of pro-oxidant and antioxidant components. Health benefit or damage can be induced as a consequence of an adaptive cellular stress response. A consequence of hormetic amplification is an increase in the homeodynamic space of a living system in terms of an increased defense capacity and a reduced load of damaged macromolecules. Ozone, when used at appropriate doses, promotes the formation of reactive oxygen species and lipid peroxides allows them to become late and long-lasting messengers. Healthy aging may be achieved by hormesis through mild and periodic, but not severe or chronic, physical and mental challenges, and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins. The paradoxical concept that ozone eventually induces an antioxidant response capable of reversing a chronic oxidative stress is common in the animal and vegetal kingdom; it is already supported by findings of an increased level of antioxidant enzymes during ozone therapy. Those facts can include ozone as a hormetin. The established scientific foundations of hormesis are ready to pave the way for new and effective approaches in redoxrelated disease research and intervention; ozone therapy can be a good candidate.

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29 Septiembre 2014
Administrator

Ozone has recently been subjected to criticism and emphasis in relation to clinical efficacy and toxicity, respectively. Without a doubt, ozone, in common with oxygen itself, is one of the most potent oxidants. Ozone is considered one of the major pollutants in urban areas. Nevertheless, increasingly widespread use lately has highlighted the potential benefits as a therapeutic agent when used according to well-defined and safe protocols. Basic studies conducted following rigorous scientific and ethical criteria have been proposed for scientific discussion. This paper concerns original data on an in vivo model of Parkinson?s disease and published data on the effect of low ozone doses with any risk of toxicity excluded with the concentrations commonly used in medical applications.

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29 Septiembre 2014
Administrator

Basic fibroblast growth factor (bFGF) is a pleiotropic mitogen which plays an important role in cell growth, differentiation, migration, and survival in different cells and organ systems. Application of bFGF has been shown to promote cellular proliferation and collagen synthesis in vivo. FGF is markedly up-regulated following bone or tendon injury and are active at multiple stages of the healing process stimulation, of local blood circulation, lipolisis and smooth muscle. Looking at physic and chemical properties of the ozone molecule, the present work deals the possible therapeutic action as a FGF activator. Incubation (2 h) of platelet rich plasma with O2/O3 80 ?g/mL increases in approximately 600% the basal concentration of FGF. This fact in combination with previous demonstration of the stimulating action of O3, releasing other platelet factors may potentially possible the autologous treatment in aesthetic and clinical tissues conditions in which FGF has a protagonist role. The versatility and amplitude of beneficial effect of ozone has become evident in orthopedics, cutaneous and mucosal infections as well as in dentistry, the induction of FGF and other growth factors by ozone can support and potentiate those applications.

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El ozono puro al ser inhalado es tóxico, pero se ha demostrado que es seguro y efectivo cuando está diluido para uso terapéutico. 

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